Two new studies conducted by U. S. researchers claim to have isolated a genetic mutations in two genes, claiming it to have links with two malignant forms of ovarian cancer with endometriosis.
Dr. David Huntsman, a genetic pathologist at the B. C. Cancer Agency, who spearheaded the study, claimed that the two cancers types -- clear-cell carcinoma and endometrioid carcinoma -- account to the second and third most common forms of prevalent ovarian tumor.
The two genes involved are claimed to be ARID1A and PPP2R1A, said Dr. Bert Vogelstein, Nickolas Papadopoulos and colleagues at Johns Hopkins University in Baltimore.
The study findings published recently in the New England Journal of Medicine have shown the genetic mutations to bear links with ovarian clear cell carcinoma, deemed to be the most malignant ovarian cancer types as these do not respond to chemotherapy.
However, researchers have highlighted that more genetic-testing tools need to be formed in a view to reach out to these genetic mutations.
ARID1A deemed as a tumor suppressor gene, is cited to have links with an initial impact of transforming endometriosis into one of two malignant forms of ovarian cancer.
The study is reported to have been based on DNA taken from over 600 ovarian tumor samples.
source: topnews.us
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